Will there be a 'Twisters' sequel? Here's what the cast says.

Twisters is officially summer's first big live-action blockbuster, as it debuted to $80.5 million at the domestic box office over the weekend. The movie stars Glen Powell and Daisy Edgar-Jones as storm chasers in the modern-day disaster flick, which is a follow-up to 1996's Twister. The cast has been careful not to call Twisters a sequel. But with the film's success, is the cast open to another chapter?

"I'm not sure," Edgar-Jones told Yahoo Entertainment as she joked, "They'd have to keep adding s's to the end of the word Twister."

Days before Twisters premiered in theaters, Powell seemed ready to leave the answer to that question up to the moviegoers.

“That's really up to the audience with a movie like this," he told Yahoo Entertainment. "If the audience proves there's a hunger there, then we have an amazing team of people that will always figure out how to make another story."

The hunger is there, as Twisters had the third-biggest opening weekend of the year, only behind Inside Out 2 and Dune: Part Two. And there is certainly one plot point left to cover, should Daisy-Jones reprise her role as Kate, a brainy meteorologist, and Powell throw a cowboy hat (and wet T-shirt) on for another ride as Tyler, the reckless social media influencer. But actress Katy O'Brian, who plays Dani in Tyler's tornado wrangling crew, felt pretty strongly when asked about the possibility of another film.

"What would it be called?" O'Brian told Yahoo. "I always feel like when a movie is just really well done and doesn't need a sequel, we just probably shouldn't do it."

However, O'Brian seemed to already know the likely answer, should Twisters perform well at the box office: "I know that people follow the money."

Actor Brandon Perea, who plays Boone in Tyler's squad of extreme storm chasers, had an idea, should acclaimed director Lee Isaac Chung want to come back for another film.

"What if we do a prequel?" Perea suggested. "I would like to learn more about the wranglers in a sense ... how did Tyler and Boone meet?"

"[A prequel] would be cool," O'Brian added. "I just feel like this movie was really complete."

Following a string of hits like Top Gun: Maverick, Anyone But You, Hit Man and now Twisters, Powell has cemented himself as the movie star of the moment. If there were to be a sequel, he would most likely need to be onboard. The actor is sitting atop studios' wish lists, in part, due to his business savvy sense of which projects to pursue and not to pursue.

"Just like this movie, you sort of have to go with your instinct on things, you know, it's part science, part instinct, and I think the science aspect of this is the team around it," Powell told Yahoo about why Twisters was a yes for him. "You have Daisy, you have Lee Isaac Chung, [executive producer] Steven Spielberg ... Then I think the instinct is just the world kind of craving this flavor."

Powell continued, "I'm trying to, right now career-wise, trust my gut and my instinct and going, like, if I wanna see this movie, I feel like other people want to see it too. And I feel like that's sort of the gut I go with."

So you're saying there's a chance...

Twisters is in theaters everywhere.