It's hard to imagine Legally Blonde without Reese Witherspoon. Or what about Titanic without Kate Winslet??? But hang on to your hats, kids, because both parts almost went to completely different actors. Whether they declined because of scheduling conflicts or due to those classic "creative differences," here are 50 actors who turned down major movie roles (and some of them probably regret their decisions, to be honest!).
Paramount | The Weinstein Company | Lionsgate
From Reese Witherspoon, who passed on Scream, to Mark Wahlberg, who passed on Brokeback Mountain.